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Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 275-289 doi: 10.1007/s11684-022-0945-y
Keywords: epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted
Toll-like receptors in innate immunity and infectious diseases
Min-Hao WU, Ping ZHANG, Xi HUANG,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 385-393 doi: 10.1007/s11684-010-0600-x
Keywords: Toll-like receptors innate immunity infectious disease inflammation
Group III metabotropic glutamate receptors and drug addiction
Limin Mao, Minglei Guo, Daozhong Jin, Bing Xue, John Q. Wang
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 445-451 doi: 10.1007/s11684-013-0291-1
Keywords: group III metabotropic glutamate receptors cocaine amphetamine alcohol opiate
Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 236-239 doi: 10.1007/s11684-009-0040-7
Keywords: protease-activated receptors platelet
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy. However, the good efficacy of CATs is rarely reported in clinical applications because CATs have no or very low antigen specificity. The low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT). Herein, we demonstrate that NY-ESO-1157–165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancer cells with good efficacy. With low micromolar range dissociation equilibrium constants, HAT-transduced CATs showed good specificity with no off-target killing. Furthermore, the high-affinity TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered T cells (TCR-Ts) in terms of interferon-g and granzyme B production and in vitro cancer cell killing ability. TCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized cyto-immunotherapy.
Keywords: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 465-472 doi: 10.1007/s11684-016-0482-7
Keywords: electroacupuncture analgesia ASIC3 TRPV1 C-fiber reflex
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
Engineering 2022, Volume 10, Issue 3, Pages 30-43 doi: 10.1016/j.eng.2021.10.018
Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that have revolutionizedCells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific
Keywords: Chimeric antigen receptors T cell Treg Alloimmunity Bioengineering Transplant Autoimmunity
Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.
Keywords: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene
Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 57-60 doi: 10.1007/s11684-009-0003-z
Keywords: receptors leptin RNA interference lentivirus vector
Title Author Date Type Operation
A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma
Journal Article
Toll-like receptors in innate immunity and infectious diseases
Min-Hao WU, Ping ZHANG, Xi HUANG,
Journal Article
Group III metabotropic glutamate receptors and drug addiction
Limin Mao, Minglei Guo, Daozhong Jin, Bing Xue, John Q. Wang
Journal Article
Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
Journal Article
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Journal Article
Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia
Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu
Journal Article
Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
Journal Article
Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors
Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu
Journal Article